A Current Assessment

نویسنده

  • Daniel Steinberg
چکیده

T he purpose of this paper is to review briefly the strengths and weaknesses of the oxidative modification hypothesis of atherogenesis. As with any new hypothesis, there is danger that the supporting evidence, even if limited, will generate enthusiasm that runs too far and too fast. Because the hypothesis has not yet been falsified, it deserves further study. It is hoped that it will stand up to closer inspection and critical evaluation. At this time, however, it remains a hypothesis that rests primarily on in vitro data, a few in vivo rabbit studies and some epidemiological correlational data. Before a clinical trial can be rationally planned, we need to learn more about the mechanisms involved, possibly critical species differences, and the pros and cons of the several potential interventions available to test the oxidative modification hypothesis.1 It would be unfortunate if the first tests of the hypothesis were done prematurely, using inadequate intervention modalities and resulting in a false negative result. Clinical trials are expensive and time consuming; they should only be undertaken when the science base is sufficiently strong.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

حمایت سازمانی از ارزیابی عملکرد دانشجویان در نظام آموزش عالی

Background and Objective : Electronic learning is a pre-construcaware of Teachers and administrators the climate university, reflect that the assessment valuable insights environment support provide of thestudent learning. Objective To study the organizational support of students performance evaluating the University the shahid Chamran of ahvaz. Materials and Methods :the survey was conducted ...

متن کامل

Condition Assessment of Metal Oxide Surge Arrester Based on Multi-Layer SVM Classifier

This paper introduces the indicators for surge arrester condition assessment based on the leakage current analysis. Maximum amplitude of fundamental harmonic of the resistive leakage current, maximum amplitude of third harmonic of the resistive leakage current and maximum amplitude of fundamental harmonic of the capacitive leakage current were used as indicators for surge arrester condition mon...

متن کامل

Community Assessment: A Current Essential Need

Health as a basic right of the people and essential demand should be considered as a joint responsibility of the government and people of a community. As much as the people of a community aware and involved in the individual health promotion and problem solving of their community in all dimensions, the probability of reaching to favorable health measurements is also increased. Community assess...

متن کامل

الگوی زایمان ایمن بر اساس حاکمیت بالینی

Background: Because of the current population policies adopted in Iran followed by increasing the number of births, this study aimed to investigate the current situation of safe delivery and proposed a model based on clinical governance. Materials and Methods: This study is a combinatorial-exploratory research (Mixed Method) conducted in four hospitals in Qazvin and Semnan provinces includ...

متن کامل

The Effect of Self-Assessment Reading Strategies on the Function of Paramedical Science Students in Comprehension Drills

Background & Aim: The new methods of examination and evaluation such as self- assessment contribute to both instructor and learner toward finding out the attitudes, viewpoints, abilities and weaknesses of learners. This kind of examination also encourages the learner toward changing to an independent learner and forms the critical way of thinking inside of himself and encourages them to lear...

متن کامل

The Effect of Self-Assessment Reading Strategies on the Function of Paramedical Science Students in Comprehension Drills

Background & Aim: The new methods of examination and evaluation such as self- assessment contribute to both instructor and learner toward finding out the attitudes, viewpoints, abilities and weaknesses of learners. This kind of examination also encourages the learner toward changing to an independent learner and forms the critical way of thinking inside of himself and encourages them to le...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005